3-Aminopropylphosphonic Acid
CAS No. 13138-33-5
3-Aminopropylphosphonic Acid ( —— )
Catalog No. M28162 CAS No. 13138-33-5
3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
Purity : >98% (HPLC)
Size | Price / USD | Stock | Quantity |
5MG | 45 | Get Quote |
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10MG | 63 | Get Quote |
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25MG | 103 | Get Quote |
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50MG | 150 | Get Quote |
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100MG | 223 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product Name3-Aminopropylphosphonic Acid
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NoteResearch use only, not for human use.
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Brief Description3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay).
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Description3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding assay). (In Vitro):3-aminopropylphosphonic acid (IC50 1.5 microM) and 4-aminobutyl-phosphonic acid (IC50 3.9 μM) were much more potent than anticipated from their relatively weak GABAB antagonist actions . 3-aminopropylphosphonic acid was a potent inhibitor (IC50 6μM) of the binding of [3H]GABA to rat brain membranes under GABAB conditions, i.e. in the presence of 0.1 mM isoguvacine and displaceable by 0.1 mM (+)-baclofen . (In Vivo):3-aminopropylphosphonic acid induces relaxation in unstimulated isolated guinea pig ileum longitudinal muscle and reverses GABA- and baclofen-induced inhibition of twitch responses in isolated guinea pig ileum longitudinal muscle. 3-APPA (5 mg/kg) completely inhibits GABA- and baclofen-induced inhibition of vagally stimulated bronchospasms in guinea pigs. It also reverses the antitussive effect of baclofen in cats when administered at a dose of 3 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number13138-33-5
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Formula Weight139.1
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Molecular FormulaC3H10NO3P
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Purity>98% (HPLC)
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Solubility——
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SMILESNCCCP(O)(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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OD1
Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.
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Activated Protein C ...
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity.
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FH1
FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.